Idebenone and
vinpocetine augment long-term potentiation in hippocampal slices in the guinea
pig.
Ishihara K, Katsuki H, Sugimura M, Satoh M.
Department of Pharmacology,
Faculty of Pharmaceutical Sciences,
Kyoto
University, Japan.
Neuropharmacology 1989 Jun;28(6):569-73
ABSTRACT
The effects of idebenone and
vinpocetine which reportedly prevent impairment of learning and memory were
studied in vitro, on the long-term potentiation of the population spike in the
pyramidal layer of CA3 region of slices of hippocampus in the guinea pig.
Idebenone (10(-9) M-10(-6) M) or vinpocetine (10(-7) M-10(-6) M) significantly
augmented long-term potentiation in the mossy fibre-CA3 pyramidal cell system,
without any significant changes in population spikes in the absence of tetanic
stimulation. These results suggest that both drugs have direct actions on the
hippocampal neurones to augment long-term potentiation at fairly small
concentrations. Further, when the two drugs were applied together, the
augmenting effects were additive.
